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Associated with the circadian disruption is the activation of mast cells by inflammatory cytokines .[ref] So it is a two-hit scenario: circadian rhythm disruption in mast cells along with elevated inflammatory cytokines

Certain secondary metabolites produced by microorganisms may influence host physiological functions, such as modulating the proliferation of rumen epithelial cells, regulating fermentation patterns, affecting appetite, or participating in immune regulation [51]